HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 54047045, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 54166902 | HCID 54166902 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 54047045 | HCID 54047045 | 81.4% |
Reaction Steps
Ammonia gas was blown into a solution of 40 mg of 3-[[(S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl]oxy]propionic acid (Example L) in 2.5 ml of acetonitrile until the solution is saturated and subsequently 50 mg of HBTU were added. Then, the mixture was filtered and evaporated and the residue was chromatographed on silica gel with 5 percent methanol in methylene chloride. There were obtained 32.5 mg of (3S,4S)-4-[(S)-2-(2-carbamoylethoxy)tridecyl]-3-hexyl-2-oxetanone, m.p. 35°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05466708 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-cc54a1b48634473cb204ba665648f9bc |
| Source note | uspto-grants-1995_11 |