Methanol → HCID 18918195, compound

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Reaction Steps

A mixture of 3.2 g of 10-(2-pyrazinylmethylene-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one, 250 ml of dimethylformamide, 50 ml of methanol and 5 ml of acetic acid is hydrogenated at a temperature in the region of 20° C. and a pressure of 1.8 bar of hydrogen, in the presence of 10% palladium on charcoal for 18 hours. The catalyst is filtered off under inert atmosphere and the filtrate is concentrated on a rotary evaporator. On addition of 200 ml of methanol a precipitate is formed which, after trituration in dichloromethane (100 ml), filtration and drying at 60° C. under vacuum (1 mmHg; 0.13 kPa), gives 1.4 g of 10-(2-pyrazinylmethyl)-5H,10H-imidazo[1,2-a]-indeno[1,2-e]pyrazin-4-one in the form of a beige solid melting above 260° C. (Analysis % calculated C: 68.56, H: 4.16, N: 22.21, O: 5.07, % found C: 68.3, H: 3.9, N: 21.9).

Provenance & Evidence