Phenyl isocyanate → HCID 18918177, compound

Participants

Reaction Conditions

Reaction Steps

To 0.5 g of 10-amino-7-chloro-5H,10H-imidazo-[1,2-a]indeno[1,2-e]pyrazin-4-one hydrochloride suspended in 8 ml of dimethyl sulphoxide is added dropwise 0.45 ml of triethylamine, followed by a solution of 0.9 ml of phenyl isocyanate in 2 ml of dimethylformamide. The reaction medium is stirred for 2 hours at a temperature in the region of 20° C. and the precipitate formed is filtered off, washed with water and dried under reduced pressure (1 mmHg; 0.13 kPa) at 50° C. 0.15 g of 7-chloro-10-(3-phenylureido)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one is thus obtained, in the form of a white solid the melting point of which is greater than 260° C. (Analysis C20H14ClN5O2 ·0.6 DMF·0.8 H2O % calculated C: 61.31; H: 3.60; Cl: 9.05; N: 17.87; % found C: 61.1; H: 3.5; Cl: 9.4; N: 17.7).

Provenance & Evidence