Dimethylformamide dimethyl acetal → 4-(4-Chlorophenoxy)-1-(dimethylamino)pent-1-en-3-one

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(4-chlorophenoxy)-2-butanone (34.50 g) and N,N-dimethylformamide dimethylacetal (20.70 g) was heated under argon in an oil bath at 120° C. for 13 hours. The methanol produced in the reaction was removed under reduced pressure and the residual oil triturated with n-hexane. The solid was collected by filtration and washed with cold diethyl ether to give 4-(4-chlorophenoxy)-1-(dimethylamino)-1-penten-3-one. Yield 32.50 g.

Provenance & Evidence