1-(4-Chlorobenzoyl)piperidin-4-one → 1-(4-Chlorobenzoyl)-4-(4-cyanobenzylidene)piperidine

HRID 129080Notes

Reaction equation

HRID 129080 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([N:8]2[CH2:13][CH2:12][C:11](=[CH:14][C:15]3[CH:20]=[CH:19][C:18]([C:21](OC)=O)=[CH:17][C:16]=3OC)[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.COC1C=C(C(OC)=O)C=CC=1CP(=O)(OCC)OCC.ClC1C=CC(C([N:57]2CCC(=O)CC2)=O)=CC=1>>[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([N:8]2[CH2:13][CH2:12][C:11](=[CH:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]#[N:57])=[CH:17][CH:16]=3)[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 152314041-(4-Chlorobenzoyl)piperidin-4-oneHCID 193726641-(4-Chlorobenzoyl)-4-(2-methoxy-4-methoxycarbonylbenzylidene)piperidineHCID 19372693Diethyl 2-methoxy-4-methoxycarbonylbenzylphosphonate

Product 1

HCID 152313981-(4-Chlorobenzoyl)-4-(4-cyanobenzylidene)piperidine

Procedure

1-(4-chlorobenzoyl)-4-(2-methoxy-4-methoxycarbonylbenzylidene)piperidine from diethyl 2-methoxy-4-methoxycarbonylbenzylphosphonate and N-(4-chlorobenzoyl)-4-piperidone. Colorless oil.

Sources & evidence

ORD record
ord-e5a47c0d0a3c4f84b07d27c3d187a01a
Source dataset
uspto-grants-1995_11
Patent number
US05466687

Reaction notes

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