反应详情

A mixture of 3-amino-1,2,4-triazole (11.74 g) and 1-chloro-1-penten-3-one (16.5 g) in acetic acid (225 ml) was heated under reflux for 45 minutes. The reaction mixture was cooled, poured onto ice and extracted with dichloromethane. The organic layer was dried and the solvent was evaporated under reduced pressure to give 7-ethyl-1,2,4-triazolo[1,5-a]pyrimidine. Yield 11.72 g.

1. temperaturewas heated
2. temperatureunder reflux for 45 minutes
3. temperatureThe reaction mixture was cooled
4. additionpoured onto ice
5. extractionextracted with dichloromethane
6. customThe organic layer was dried
7. customthe solvent was evaporated under reduced pressure