m-Chloroperbenzoic acid → HCID 9839383, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-chloroperbenzoic acid (0.63 g) in dichloromethane (30 ml) was added dropwise at -78° C. to a stirred solution of 7-{1-[4-(methylthio)phenoxy]ethyl}-1,2,4-triazolo[1,5-a]pyrimidine (0.89 g, prepared in a similar manner to that described in Example 9) in dichloromethane (30 ml). The reaction mixture was stirred at -78° C. for 2 hours, washed with a 10% aqueous solution of sodium hydrogen carbonate followed by water. The organic layer was dried and the solvent was evaporated under reduced pressure. The residue was purified by flash chromatography using as eluent a mixture of dichloromethane and ethanol (in the ratio of 95:5 respectively), followed by recrystallisation from a mixture of ethyl acetate and hexane, to give 7-[1-(4-methylsulphinylphenoxy)ethyl]-1,2,4-triazolo[1,5-a]pyrimidine. Yield 0.76 g, (m.p. 89°-102° C.).

Provenance & Evidence