HCID 3042017, compound → HCID 18919358, compound

Participants

Reaction Steps

A mixture of 1-chloro-4-methyl-1-penten-3-one (5.83 g), 3-amino-1,2,4-triazole (3.69 g) and glacial acetic acid was heated under reflux for 1 hour and 30 minutes. The reaction mixture was poured onto ice and extracted with dichloromethane. The organic layer was dried over magnesium sulphate and the solvent was evaporated to give a product which was recrystallised from petroleum ether (b.p. 100°-140° C.), to give 7-(1-methylethyl)-1,2,4-triazolo[1,5-a]pyrimidine. Yield 4.18 g.

Provenance & Evidence