4-Chlorophenol → HCID 9817423, compound

Participants

Reaction Steps

A mixture of 7-(1-bromo-1-methylethyl)-1,2,4-triazolo[1,5-a]pyrimidine (2.95 g, prepared in a similar manner to that described above), 4-chlorophenol (1.56 g), sodium bicarbonate (1 g), nickel acetyl acetone (5 mg) and dry toluene (80 ml) was stirred and heated under reflux for 7 days. The solvent was evaporated and the crude product was purified by flash chromatography using as eluent a mixture of toluene and ethylacetate (in the ratio 5:1 respectively), followed by recrystallisation from n-hexane, to give 7-[1-(4-chlorophenoxy)-1-methylethyl]-1,2,4-triazolo[1,5-a]pyrimidine. Yield 0.67 g, (mp 132°-135° C.).

Provenance & Evidence