Phosphorus pentachloride → HCID 18919386, compound

HRID 1290833Notes

Reaction equation

HRID 1290833 reaction equation
[C:1]([N:4]([C:20](=[O:22])[CH3:21])[C:5]1[C:10]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:9][CH:8]=[CH:7][C:6]=1[S:16](O)(=[O:18])=[O:17])(=[O:3])[CH3:2].P(Cl)(Cl)(Cl)(Cl)[Cl:24]>ClCCl>[C:1]([N:4]([C:20](=[O:22])[CH3:21])[C:5]1[C:10]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:9][CH:8]=[CH:7][C:6]=1[S:16]([Cl:24])(=[O:18])=[O:17])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 18919378HCID 18919378, compound

Product 1

HCID 18919386HCID 18919386, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1.55 g (3.6 mmol) of 2-(diacetylamino)-3-cyclopentylbenzenesulphonic acid and 1.12 g (5.4 mmol) of phosphorus pentachloride in 10 ml of dichloromethane is heated at the reflux temperature for 2.5 hours, and the reaction medium is then concentrated under reduced pressure. The residue thus obtained is purified by chromatography on a column of florisil™, eluting with dichloromethane.

Workup

  1. concentrationthe reaction medium is then concentrated under reduced pressure
  2. customThe residue thus obtained
  3. customis purified by chromatography on a column of florisil™
  4. washeluting with dichloromethane

Sources & evidence

ORD record
ord-dd96ca306a424c5287d659db7d10d73c
Source dataset
uspto-grants-1998_05
Patent number
US05753667

Reaction notes

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