Sodium Hydroxide → HCID 15289130, compound

HRID 1290862Notes

Reaction equation

HRID 1290862 reaction equation
[CH2:1]([N:8]1[C:16](=[O:17])[CH:15]2[CH:10]([C:11]3([C:19]([O:21]CC)=[O:20])[CH2:18][CH:14]2[CH:13]=[CH:12]3)[C:9]1=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH2:1]([N:8]1[C:16](=[O:17])[CH:15]2[CH:10]([C:11]3([C:19]([OH:21])=[O:20])[CH2:18][CH:14]2[CH:13]=[CH:12]3)[C:9]1=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15289129HCID 15289129, compound

Product 1

HCID 15289130HCID 15289130, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

30 g (90 mmol) of ethyl 4benzyl-3,5-dioxo-4-azatricyclo[5.2.1.02,6 ]dec-8-ene-1-carboxylate are heated under reflux with 5.3 g (0.13 mol) of NaOH in 150 ml of methanol overnight. The mixture is concentrated, the residue is taken up in 150 ml of water and the mixture is acidified with hydrochloric acid. The product which crystallizes out is filtered off with suction, washed with water and dried in air.

Workup

  1. concentrationThe mixture is concentrated
  2. customThe product which crystallizes out
  3. filtrationis filtered off with suction
  4. washwashed with water
  5. customdried in air

Sources & evidence

ORD record
ord-397cbc008aa84bdca0973fb7b59fa718
Source dataset
uspto-grants-1998_05
Patent number
US05753669

Reaction notes

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