Potassium Hydroxide → HCID 13565856, compound

HRID 1290884Notes

Reaction equation

HRID 1290884 reaction equation
Cl.[NH2:2][CH:3]1[CH2:9][CH:8]2[NH:10][CH:5]([CH2:6][CH2:7]2)[CH2:4]1.[OH-].[K+]>C(O)C>[NH2:2][CH:3]1[CH2:4][CH:5]2[NH:10][CH:8]([CH2:7][CH2:6]2)[CH2:9]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 18919578HCID 18919578, compound

Product 1

HCID 13565856HCID 13565856, compoundYield 35.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

After completion of the hydrogenation, insoluble matters were filtered off and 40 ml of conc. hydrochloric acid was added to the filtrate. The solvent was distilled off under vacuum and the residue was recrystallized from ethanol to give 8.3 g of 3-amino-8-azabicyclo[3.2.1]octane hydrochloride. After 8.3 g of the hydrochloride was added to 100 ml of ethanol, a solution of 5.2 g of potassium hydroxide in 50 ml of ethanol was added to the mixture followed by stirring at room temperature for 3 hours. Insoluble matters were filtered off and the solvent was then distilled off to give 2.3 g of 3-amino-8-azabicyclo[3.2.1]octane.

Workup

  1. filtrationInsoluble matters were filtered off
  2. distillationthe solvent was then distilled off

Sources & evidence

ORD record
ord-f61dbc2b477d4411ac458a90a82b4fd3
Source dataset
uspto-grants-1998_05
Patent number
US05753673

Reaction notes

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