HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-((Propan-2-yl)amino)benzaldehyde | HCID 11041035 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate | HCID 15468682 | 163.7% |
Reaction Steps
A solution of 20.0 g of 2-isopropylaminobenzaldehyde, 29.4 g of diethyl malonate, 10 ml of piperidine, 10 ml of acetic acid and 500 ml of toluene was heated to reflux for 13 hours. The reaction solution was washed with water and then with saturated sodium hydrogencarbonate aqueous solution, and dried over anhydrous magnesium sulfate. The solvent was distilled off to give 52 g of ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate as the crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05753673 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-25437f40d43f43cbb58bd11a5bdc9e43 |
| Source note | uspto-grants-1998_05 |