HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 6-[([1,1'-Biphenyl]-2-ylcarbonyl)amino]-3-pyridinecarbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6-[([1,1'-Biphenyl]-2-carbonyl)amino]pyridine-3-carboxylic acid | HCID 22099739 | — |
| Product | 6-[([1,1'-Biphenyl]-2-ylcarbonyl)amino]-3-pyridinecarbonyl chloride | HCID 22099792 | — |
Reaction Steps
A mixture of 1.9 g of 6-[(2-biphenylcarbonyl)amino]pyridine-3-carboxylic acid and 9 ml of thionyl chloride is refluxed for 1 hour and then concentrated to dryness under vacuum. Toluene (15 ml) is added (twice) to the residue and the solvent removed under vacuum to give 2.1 g of a light brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05753648 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-8d271dec39a14b4ab9de4ad8b2fdfb27 |
| Source note | uspto-grants-1998_05 |