Water → HCID 22099855, compound

HRID 1290932Notes

Reaction equation

HRID 1290932 reaction equation
[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:2]([C:7]([NH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[C:12]([Cl:20])[CH:11]=2)=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.O>C(O)C.[OH-].[Na+]>[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:2]([C:7]([NH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([OH:16])=[O:15])=[C:12]([Cl:20])[CH:11]=2)=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 962WaterHCID 22099535HCID 22099535, compound

Product 1

HCID 22099855HCID 22099855, compoundYield 3.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 3.0 g of methyl 4-[([1,1'-biphenyl]-2-carbonyl)amino]-2-chlorobenzoate in 75 ml of absolute ethanol and 2.0 ml of 10N sodium hydroxide is heated on a steam bath for 3 hours. water is added to obtain a solution which is extracted with methylene chloride. The aqueous phase is acidified with acetic acid and the resulting solid collected and dried in vacuo at 80° C. to give 0.1 g of the desired product as a crystalline solid, m.p. 217°-219° C.

Workup

  1. temperatureis heated on a steam bath for 3 hours
  2. customto obtain a solution which
  3. extractionis extracted with methylene chloride
  4. customthe resulting solid collected
  5. customdried in vacuo at 80° C.

Sources & evidence

ORD record
ord-1a172c71788f4a8aa77bdce2a070bd27
Source dataset
uspto-grants-1998_05
Patent number
US05753648

Reaction notes

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