Methyl 4-[(biphenyl-2-carbonyl)-amino]-benzoate → 4-[(2-phenylbenzoyl)amino]benzoic Acid

HRID 1290933Notes

Reaction equation

HRID 1290933 reaction equation
[C:1]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:2]([C:7]([NH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([O:16]C)=[O:15])=[CH:12][CH:11]=2)=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1>C(O)C.[OH-].[Na+]>[C:1]1([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:2]([C:7]([NH:9][C:10]2[CH:19]=[CH:18][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)=[O:8])=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 7901139Methyl 4-[(biphenyl-2-carbonyl)-amino]-benzoate

Product 1

HCID 105435024-[(2-phenylbenzoyl)amino]benzoic Acid

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A 3.15 g sample of methyl 4-[([1,1'-biphenyl]-2-carbonyl)amino]benzoate is refluxed for 8 hours in 100 ml of ethyl alcohol and 2.5 ml of 10N sodium hydroxide. The cooled reaction mixture is acidified with [[? acid]] and the desired product collected and dried to give 2.9 g of the desired product as a solid m.p. 246°-249° C. M+H=318.

Workup

  1. customThe cooled reaction mixture
  2. customthe desired product collected
  3. customdried

Sources & evidence

ORD record
ord-86af79ae6b31449e92f2bd69bf98d30e
Source dataset
uspto-grants-1998_05
Patent number
US05753648

Reaction notes

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