N,N-Dimethyl-1,3-propanediamine → HCID 18917494, compound

HRID 1290961Notes

Reaction equation

HRID 1290961 reaction equation
[CH:1]1[CH:2]=[CH:3][N:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24]([C:26]4[C:27](Cl)=[N:28][CH:29]=[CH:30][CH:31]=4)=[O:25])=[CH:19][CH:18]=3)=[O:16])[CH2:6][C:5]=12.[CH3:33][N:34]([CH3:39])[CH2:35][CH2:36][CH2:37][NH2:38]>>[CH:1]1[CH:2]=[CH:3][N:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24]([C:26]4[C:27]([NH:38][CH2:37][CH2:36][CH2:35][N:34]([CH3:39])[CH3:33])=[N:28][CH:29]=[CH:30][CH:31]=4)=[O:25])=[CH:19][CH:18]=3)=[O:16])[CH2:6][C:5]=12

Participants

3

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 18917489HCID 18917489, compound

Product 1

HCID 18917494HCID 18917494, compound

Procedure

Using the conditions of Example 334 and N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2-chloropyridine-3-carboxamide and 3-(dimethylamino)propylamine gives 900 mg of the desired product: M+ =508.

Sources & evidence

ORD record
ord-9081f5d7fa514edcbfd1c1f1beafa5d5
Source dataset
uspto-grants-1998_05
Patent number
US05753648

Reaction notes

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