反应详情

温度

0 °C

To a stirred mixture of 5-methyluridine (12.8 g, 50 mmol) in pyridine (75 mL) at 0° C. was added methanesulfonyl chloride (17.4 mL, 225 mmol). The reaction mixture was stirred at 0° C. for five hours then poured into ice-water (500 mL) with stirring. Trimethanesulfonyl-5-methyluridine (2) precipitated and the mixture was stirred for 5 min. The solid product was collected by filtration and washed with water (3×200 mL) and dried. Yield, 21.6 g, 89%.

1. stirringwith stirring
2. customTrimethanesulfonyl-5-methyluridine (2) precipitated
3. stirringthe mixture was stirred for 5 min
4. filtrationThe solid product was collected by filtration
5. washwashed with water (3×200 mL)
6. customdried
7. customYield