HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 7,8-Dihydro-6-(4-acetamidophenyl)methylidene-3-methylquinolin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Acetamidobenzaldehyde | HCID 73942 | — |
| Reactant | 3-Methyl-7,8-dihydroquinolin-5(6H)-one | HCID 595192 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 7,8-Dihydro-6-(4-acetamidophenyl)methylidene-3-methylquinolin-5-one | HCID 54078962 | 73.7% |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
7,8-Dihydro-3-methylquinoline-5[6H]one (8 g) was mixed with 4-acetamidobenzaldehyde (9 g) and piperidine (0.5 ml) and heated at 110° C. for 3 hours. Ethyl acetate (30 ml) was added to the hot reaction mixture and the mixture allowed to cool. Crystals formed and were isolated by filtration, then washed with diethyl ether to give the title compound (11.2 g). A portion was recrystallised from ethyl acetate to give an analytical sample, mp 226°-228° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05753676 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-3fde01d13b2c4c5184966492113c001c |
| Source note | uspto-grants-1998_05 |