5-cyanobenzofuran-2-carboxylic Acid → t-Butyl 3-[4-[(5-cyano-2-benzofuranyl)carbonylamino]cyclohexyl]propionate

Participants

Reaction Steps

In the same manner as in Example 1 (2), 5-cyano-2-benzofurancarboxylic acid (203 mg, 1.08 mmol) and t-butyl 3-(4-aminocyclohexyl)propionate (295 mg, 1.30 mmol) were condensed and purified by silica gel column chromatography (n-hexane/ethyl acetate=2/1) to give 165 mg of t-butyl 3-[4-[(5-cyano-2-benzofuranyl)carbonylamino]cyclohexyl]propionate as a colorless solid (38%).

Provenance & Evidence