5-Cyano-3-methyl-2-benzofurancarboxylic acid → HCID 178429365, compound

HRID 1291002Notes

Reaction equation

HRID 1291002 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([OH:13])=O)=[C:8]([CH3:14])[C:7]=2[CH:15]=1)#[N:2].[NH2:16][C@H:17]1[CH2:22][CH2:21][C@H:20]([O:23][CH2:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:19][CH2:18]1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([NH:16][C@H:17]3[CH2:22][CH2:21][C@H:20]([O:23][CH2:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:19][CH2:18]3)=[O:13])=[C:8]([CH3:14])[C:7]=2[CH:15]=1)#[N:2]

Participants

3

Reactant 2

HCID 218445275-Cyano-3-methyl-2-benzofurancarboxylic acidHCID 178451370HCID 178451370, compound

Product 1

HCID 178429365HCID 178429365, compoundYield 84%

Procedure

In the same manner as in Example 1 (2), 5-cyano-3-methyl-2-benzofurancarboxylic acid (312 mg, 1.55 mmol) and t-butyl trans-(4-aminocyclohexyloxy)acetate (380 mg, 1.66 mmol) were condensed to give 534 mg of t-butyl trans-[4-[(5-cyano-3-methyl-2-benzofuranyl) carbonylamino]cyclohexyloxy]acetate as a colorless solid (84%).

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-fb3415f42bb54562a98a532168b85fc1
Source dataset
uspto-grants-1998_05
Patent number
US05753670

Reaction notes

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