5-cyanobenzofuran-2-carboxylic Acid → HCID 178451372, compound

HRID 1291005Notes

Reaction equation

HRID 1291005 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([OH:13])=O)=[CH:8][C:7]=2[CH:14]=1)#[N:2].[NH2:15][C@H:16]1[CH2:21][CH2:20][C@H:19]([O:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:18][CH2:17]1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([NH:15][C@H:16]3[CH2:21][CH2:20][C@H:19]([O:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:18][CH2:17]3)=[O:13])=[CH:8][C:7]=2[CH:14]=1)#[N:2]

Participants

3

Reactant 2

HCID 102360545-cyanobenzofuran-2-carboxylic AcidHCID 178451370HCID 178451370, compound

Product 1

HCID 178451372HCID 178451372, compoundYield 78%

Procedure

The same method as in Example 18 was employed. That is, 5-cyano-2-benzofurancarboxylic acid (749 mg, 4.00 mmol) and t-butyl trans-(4-aminocyclohexyloxy)acetate (917 mg, 4.00 mmol) were condensed to give 1.24 g of t-butyl trans-[4-[(5-cyano-2-benzofuranyl)carbonylamino]cyclohexyloxy]acetate as a colorless solid (78%).

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-3084febb64ca486d8e8a6b4fb245c816
Source dataset
uspto-grants-1998_05
Patent number
US05753670

Reaction notes

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