6-cyano-1H-indole-2-carboxylic Acid → HCID 178451371, compound

Participants

Reaction Steps

In the same manner as in Example 1 (2), 6-cyano-2-indolecarboxylic acid (244 mg, 1.31 mmol) and t-butyl trans-(4-aminocyclohexyloxy)acetate (300 mg, 1.31 mmol) were condensed. The reaction mixture was purified by silica gel column chromatography (chloroform/methanol=50/1-1/1) to give 465 mg of t-butyl trans-[4-[(6-cyano-2-indolyl)carbonylamino]cyclohexyloxy]acetate as a brown solid (89%).

Provenance & Evidence