Imidazole → HCID 86752580, compound

Participants

Reaction Steps

A solution of 2.54 g of guanidine and 2.41 g of methyl 2-methyl-4-(1-imidazolyl)-5-methylsulfonylbenzoate [obtainable by reacting 2-methyl-4-chloro-5-methyl-sulfonylbenzoic acid with imidazole in the presence of NaH in N-methylpyrrolidone followed by esterification] in 20 ml of methanol is stirred at 500 for 3 hours. Water is then added to the reaction mixture, and the crude product which precipitates out is filtered off with suction and recrystallized from methanol. N-Diaminomethylene-2-methyl-4-(1-imidazolyl)-5-methyl-sulfonylbenzamide, m.p. 236°, is obtained.

Provenance & Evidence