[4-(2-Methylimidazol-1-yl)phenyl]methanol → 4-Methoxy-4-[3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran

HRID 1291046Notes

Reaction equation

HRID 1291046 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:14]=[CH:13][C:10]([CH2:11][OH:12])=[CH:9][CH:8]=2)[CH:4]=[CH:5][N:6]=1.O[C:16]1[CH:17]=[C:18]([C:22]2([O:28][CH3:29])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[CH:19]=[CH:20][CH:21]=1.N1(C2C=CC(COC3C=C(C4(OC)CCOCC4)C=CC=3)=CC=2)C=CN=C1>>[CH3:29][O:28][C:22]1([C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([O:12][CH2:11][C:10]3[CH:13]=[CH:14][C:7]([N:3]4[CH:4]=[CH:5][N:6]=[C:2]4[CH3:1])=[CH:8][CH:9]=3)[CH:17]=2)[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1

Participants

4

Reactant 3

HCID 11735617[4-(2-Methylimidazol-1-yl)phenyl]methanolHCID 149858684-(3-hydroxyphenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyranHCID 189201804-[3-[4-(1-Imidazolyl)benzyloxy]phenyl]-4-methoxy-3,4,5,6-tetrahydro-2H-pyran

Product 1

HCID 98860694-Methoxy-4-[3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran

Procedure

The title compound was prepared from 4-(2-methylimidazol-1-yl)benzyl alcohol and 4-(3-hydroxyphenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyran according to the procedure described for 4-[3-[4-(1-imidazolyl)benzyloxy]phenyl]-4-methoxy-3,4,5,6-tetrahydro-2H-pyran. (Example 1)

Sources & evidence

ORD record
ord-a788130578db41e1a3f76b5506effacd
Source dataset
uspto-grants-1998_05
Patent number
US05753682

Reaction notes

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