4-Fluorobenzaldehyde → 4-Methoxy-4-[3-[4-(4-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran

HRID 1291047Notes

Reaction equation

HRID 1291047 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.FC1C=CC(C=O)=CC=1.[CH3:16][O:17][C:18]1([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH2:31][C:32]3[CH:37]=[CH:36][C:35](N4C=CN=C4C)=[CH:34][CH:33]=3)[CH:25]=2)[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>>[CH3:16][O:17][C:18]1([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH2:31][C:32]3[CH:37]=[CH:36][C:35]([N:5]4[CH:6]=[C:2]([CH3:1])[N:3]=[CH:4]4)=[CH:34][CH:33]=3)[CH:25]=2)[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1

Participants

4

Reactant 3

HCID 680234-FluorobenzaldehydeHCID 98860694-Methoxy-4-[3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyranHCID 178418800HCID 178418800, compound

Product 1

HCID 189201834-Methoxy-4-[3-[4-(4-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran

Procedure

The title compound was prepared using 4-methylimidazole and 4-fluorobenzaldehyde according to the procedure as described for 4-methoxy-4-[3-[4-(2-methylimidazol- 1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran (Example 2).

Sources & evidence

ORD record
ord-4adf1513d4874f1e8b40642506107508
Source dataset
uspto-grants-1998_05
Patent number
US05753682

Reaction notes

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