Benzoyl chloride → N-benzoylcyanoacetic hydrazide

HRID 129105Notes

Reaction equation

[C:1]([CH2:3][C:4]([NH:6][NH2:7])=[O:5])#[N:2].[C:8](Cl)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:8]([N:6]([C:4](=[O:5])[CH2:3][C:1]#[N:2])[NH2:7])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 8820Cyanoacetic acid hydrazide

Product 1

HCID 19373546N-benzoylcyanoacetic hydrazide

Procedure

in a second step treating the as-synthesized cyanoacetic hydrazide with benzoyl chloride in the presence of a buffer system to form an N-benzoylcyanoacetic hydrazide, and thereafter

Sources & evidence

ORD record: ord-8f8f393981c14f1e96c44543a2072323
Source dataset: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05466812

Reaction notes

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