4-Fluorobenzaldehyde → 4-Methoxy-4-[3-[4-(4-phenylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran

HRID 1291050Notes

Reaction equation

HRID 1291050 reaction equation
[C:1]1([C:7]2[N:8]=[CH:9][NH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC1C=CC(C=O)=CC=1.[CH3:21][O:22][C:23]1([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH2:36][C:37]3[CH:42]=[CH:41][C:40](N4C=CN=C4C)=[CH:39][CH:38]=3)[CH:30]=2)[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[CH3:21][O:22][C:23]1([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH2:36][C:37]3[CH:42]=[CH:41][C:40]([N:10]4[CH:11]=[C:7]([C:1]5[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=5)[N:8]=[CH:9]4)=[CH:39][CH:38]=3)[CH:30]=2)[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 680234-FluorobenzaldehydeHCID 98860694-Methoxy-4-[3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyranHCID 178418822HCID 178418822, compound

Product 1

HCID 189201614-Methoxy-4-[3-[4-(4-phenylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran

Procedure

The title compound was prepared from 4-phenylimidazole and 4-fluorobenzaldehyde according to the general procedure described for 4-methoxy-4-[3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran (Example 2).

Sources & evidence

ORD record
ord-4449795e61734683a1de811030eb51d6
Source dataset
uspto-grants-1998_05
Patent number
US05753682

Reaction notes

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