HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fumaric Acid → 4-[5-fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-4-methoxy-3,4,5,6-tetrahydro-2H-pyran fumarate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | 4-(5-fluoro-3-(4-(2-methyl-1H-imidazol-1-yl)benzyloxy)phenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyran | HCID 10386055 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[5-fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-4-methoxy-3,4,5,6-tetrahydro-2H-pyran fumarate | HCID 18920181 | 78% |
Reaction Steps
To a solution of 4-[5-fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-4-methoxy-3,4,5,6-tetrahydro-2H-pyran (150 mg, 0.38 mmol) in MeOH (3 ml) was added fumaric acid (44 mg, 0.38 mmol). The resulting solution was concentrated in vacuo. The residual solid was recrystallized from ethanol to afford 152 mg (77%) of 4-[5-fluoro-3-[4-(2-methylimidazol- 1-yl)benzyloxy]phenyl]-4-methoxy-3,4,5,6-tetrahydro-2H-pyran fumarate as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05753682 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-d8e6d36c431046c3866d8772099d9df7 |
| Source note | uspto-grants-1998_05 |