Trifluoroacetic acid → HCID 18919889, compound

Participants

Reaction Steps

0.14 g (0.00101 mol) of 2-amino-nicotinic acid was suspended in 50 ml of THF and treated with 0.077 ml (0.00101 mol) of trifluoroacetic acid. The mixture was stirred at room temperature for 1 hr., whereby a solution resulted. To this was added 0.25 g (0.0015 mol) of carbonyidiimidazole and the mixture was stirred at room temperature for 2 hrs. Subsequently, 0.34 g (0.00178 mol) of 1-benyl-4-hydroxy-piperidine was added and the mixture was stirred at 60° for 72 hrs. After removing the solvent the residue was chromato-graphed over silica gel with ethyl acetate/hexane (1:1) as the eluent. 0.105 g (31%) of 1-benzyl-piperidin-4-yl 2-amino-nicotinate was obtained as white crystals. MS: me/e (% basic peak)=311 (C18H21N3O2+, 7.5), 173 (42), 91 (100), 82 (86).

Provenance & Evidence