Triethylamine → HCID 18919848, compound

Participants

Reaction Steps

0.3 g (0.0015 mol) of 1-benzyl-4-hydroxypiperidine and 0.216 ml (0.00155 mol) of triethylamine were dissolved in 20 ml of toluene and treated with 0.21 ml (0.0016 mol) of 4-chloro-benzoyl chloride. The mixture was boiled at reflux for 6 hrs., the precipitate was filtered off and the filtrate was concentrated. The residue was chromatographed over silica gel with ethyl acetate/hexane (1:2). 0.404 g (82%) of 1-benzyl-piperidin-4-yl 4-chloro-benzoate was obtained as a colorless oil. MS: me/e (% basic peak)=329 (C19H20CINO2+, 7), 252 (7), 173 (32), 139 (15), 91 (91), 82 (100).

Provenance & Evidence