Triethylamine → HCID 18919748, compound

Participants

Reaction Steps

0.5 g (0.00216 mol) of 1-benzyl-4-hydroxypiperidine and 0.64 ml (0.0046 mol) of triethylamine were dissolved in 20 ml of toluene and treated with 0.37 ml (0.0027 mol) of 3-bromo-benzoyl chloride. The mixture was boiled at reflux for 6 hrs., the precipitate was filtered off and the filtrate was concentrated. The residue was chromatographed over silica gel with ethyl acetate/hexane (1:3). 0.79 g (98%) of 1-benzyl-piperidin-4-yl 3-bromo-benzoate was obtained as a colorless oil.

Provenance & Evidence