Triethylamine → HCID 18919792, compound

Participants

Reaction Steps

1.0 g (0.00532 mol) of 1-benzyl-4-hydroxypiperidine and 0.72 ml (0.00532 mol) of triethylamine were dissolved in 50 ml of toluene and treated with 0.7 ml (0.00532 mol) of o-toluoyl chloride. The mixture was boiled at reflux for 2 hrs., the precipitate was filtered off and the filtrate was concentrated. The residue was chromatographed over silica gel with ethyl acetate/hexane (1:1). 1.3 g (80%) of 1-benzyl-piperidin-4-yl 2-methyl-benzoate were obtained as a brownish oil. MS: me/e (% basic peak)=309 (C20H23NO2+, 6), 232 (5.5), 173 (22.6), 119 (17.2), 91 (100), 82 (96).

Provenance & Evidence