Triethylamine → HCID 18919772, compound

Participants

Reaction Steps

1.0 g (0.00532 mol) of 1-benzyl-4-hydroxypiperidine and 0.72 ml (0.00532 mol) of triethylamine were dissolved in 50 ml of toluene and treated with 0.7 ml (0.00532 mol) of p-toluoyl chloride. The mixture was boiled at reflux for 2 hrs., the precipitate was filtered off and the filtrate was concentrated. The residue was chromatographed over silica gel with ethyl acetate/hexane (1:3). 1.3 g (80%) of 1-benzyl-piperidin-4-yl 4-methyl-benzoate was obtained as white crystals; m.p. 73°-74°.

Provenance & Evidence