Thionyl Chloride → 2-Nitro-4-(trifluoromethyl)benzoyl chloride

HRID 1291109Notes

Reaction equation

HRID 1291109 reaction equation
[N+:1]([C:4]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:5]=1[C:6](O)=[O:7])([O-:3])=[O:2].S(Cl)([Cl:19])=O>>[N+:1]([C:4]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:5]=1[C:6]([Cl:19])=[O:7])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 6420962-Nitro-4-(trifluoromethyl)benzoic acid

Product 1

HCID 143235242-Nitro-4-(trifluoromethyl)benzoyl chlorideYield 94%

Procedure

0.56 g (0.00238 mol) of 2-nitro-4-trifluoromethyl-benzoic acid was dissolved in 7 ml of thionyl chloride and boiled under reflux for 2 hrs. The reaction mixture was concentrated and the residue was taken up twice in toluene and evaporated to dryness each time. 0.53 g (94%) of 2-nitro-4-trifluoromethyl-benzoyl chloride was obtained as a yellow oil.

Workup

  1. temperatureunder reflux for 2 hrs
  2. concentrationThe reaction mixture was concentrated
  3. customevaporated to dryness each time

Sources & evidence

ORD record
ord-4a87d6616d47415b960620856e46414b
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

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