HCID 18919793, compound → HCID 18919759, compound

Participants

Reaction Steps

0.25 g (0.000612 mol) of 1-benzyl-piperidin-4-yl 2-nitro-4-trifluoromethyl-benzoate was dissolved in 10 ml of ethanol and treated with 0.15 g of Raney-nickel. The mixture was hydrogenated at room temperature under normal pressure for 2 hrs. The catalyst was filtered off and the solvent was removed completely. The residue was chromatographed over silica gel with ethyl acetate/hexane (1:1) as the eluent. 0.11 g (48%) of 1-benzyl-piperidin-4-yl 2-amino-4-trifluoromethyl-benzoate was obtained as a yellow oil. MS: me/e=379 (C20H22F3N2 O2 +).

Provenance & Evidence