HCID 18919860, compound → HCID 18919912, compound

HRID 1291115Notes

Reaction equation

HRID 1291115 reaction equation
[NH2:1][C:2]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:3]=1[C:4]([O:6][CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:9][CH2:8]1)=[O:5]>CCOCC>[ClH:24].[NH2:1][C:2]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:3]=1[C:4]([O:6][CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:9][CH2:8]1)=[O:5]

Participants

3

Reactant 1

HCID 18919860HCID 18919860, compound

Product 1

HCID 18919912HCID 18919912, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.11 g (0.00032 mol) of 1-benzyl-piperidin-4-yl 2-amino-4-chloro-benzoate was dissolved in 10 ml of ether, filtered, diluted with 1 ml of methanol and treated with 1 ml of 1N ethereal HCI. The mixture was stirred for 2 hrs. The separated precipitate was filtered off and dried in a high vacuum. 0.05 g (41%) of 1-benzyl-piperidin-4-yl 2-amino-4-chloro-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 135°-137°.

Workup

  1. filtrationfiltered
  2. additiondiluted with 1 ml of methanol
  3. additiontreated with 1 ml of 1N ethereal HCI
  4. filtrationThe separated precipitate was filtered off
  5. customdried in a high vacuum

Sources & evidence

ORD record
ord-9aa900279aa54852aedc17e660e3eac3
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

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