HCID 18919914, compound → HCID 18919885, compound

Participants

Reaction Steps

0.19 g (0.000537 mol) of 1-benzyl-piperidin-4-yl 2-amino-4-nitro-benzoate was dissolved in 16 ml of ethanol, treated with 0.115 g of Raney-Nickel and hydrogenated under normal pressure. The catalyst was filtered off, the solvent was removed on a rotary evaporator and the residue was chromatoraphed on silica gel with ethyl acetate/hexane (1:1→1:1) as the eluent. 0.155 g (89%) of 1-benzyl-piperidin-4-yl 2,4-diamino-benzoate was obtained as white crystals.

Provenance & Evidence