Triethylamine → HCID 18919901, compound

Participants

Reaction Steps

0.25 g (0.0011 mol) of 1-(3-chloro-benzyl)-piperidin-4-ol and 0.39 ml (0.0028 mol) of triethylamine were dissolved in 11 ml of toluene, treated with 0.184 ml (0.0014 mol) of p-toluoyl chloride and boiled at reflux for 18 hrs. The reaction mixture was concentrated and the residue was chromatographed over silica gel with ethyl acetate/hexane (1:3). 0.155 g (41%) of 1-(3-chloro-benzyl)-piperidin-4-yl 4-methyl-benzoate was obtained as a colorless oil.

Provenance & Evidence