HCID 18919901, compound → HCID 18919900, compound

HRID 1291143Notes

Reaction equation

HRID 1291143 reaction equation
[CH3:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1>CCOCC>[ClH:22].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:23][CH:24]=1

Participants

3

Reactant 1

HCID 18919901HCID 18919901, compound

Product 1

HCID 18919900HCID 18919900, compoundYield 118.2%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.153 g (0.000445 mol) of 1-(3-chloro-benzyl)-piperidin-4-yl 4-methyl-benzoate was dissolved in 13 ml of ether, filtered, diluted with 0.45 ml of methanol and treated with 1.5 ml of 1N ethereal HCI. The separated precipitate was filtered off and dried. 0.10 g (59%) of 1-(3-chloro-benzyl)-piperidin-4-yl 4-methyl-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 226°-228°.

Workup

  1. filtrationfiltered
  2. additiondiluted with 0.45 ml of methanol
  3. additiontreated with 1.5 ml of 1N ethereal HCI
  4. filtrationThe separated precipitate was filtered off
  5. customdried

Sources & evidence

ORD record
ord-9e3718978bc24aeb99c21aec832642d3
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

Loading…