HCID 18919796, compound → HCID 18919851, compound

HRID 1291146Notes

Reaction equation

HRID 1291146 reaction equation
[C:1]([O:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOCC>[ClH:23].[C:1]([O:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[CH2:14][CH2:15]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 18919796HCID 18919796, compound

Product 1

HCID 18919851HCID 18919851, compoundYield 181.3%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.165 g (0.0005 mol) of 1-(4-chloro-benzyl)-piperidin-4-yl benzoate was dissolved in 15 ml of ether, filtered, diluted with 0.6 ml of methanol and treated with 5 ml of 1N ethereal HCI. The separated precipitate was filtered off and dried. 0.166 g (90.6%) of 1-(4-chloro-benzyl)-piperidin-4-yl benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 216°-217°.

Workup

  1. filtrationfiltered
  2. additiondiluted with 0.6 ml of methanol
  3. additiontreated with 5 ml of 1N ethereal HCI
  4. filtrationThe separated precipitate was filtered off
  5. customdried

Sources & evidence

ORD record
ord-a0627cb6c50a404fa4e4ca32171a8cf6
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

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