HCID 18919779, compound → HCID 18919784, compound

Participants

Reaction Steps

0.345 g (0.00101 mol) of 1-(2-nitro-benzyl)-piperidin-4-yl benzoate was dissolved in 15 ml of ethanol and treated with 0.2 g of Raney-nickel. The mixture was hydrogenated at room temperature and under normal pressure for 8 hrs. The catalyst was filtered off and, after concentration, the residue was chromatographed on silica gel with ethyl acetate/ hexane (1:3) as the eluent. 0.197 g (61%) of 1-(2-amino-benzyl)-piperidin-4-yl benzoate was obtained as a colorless oil. MS: me/e=311 (C19H23N2 O2+).

Provenance & Evidence