Benzoyl chloride → HCID 18919855, compound

Participants

Reaction Steps

0.5 g (0.00212 mol) of 1-(3-nitro-benzyl)-piperidin-4-ol and 0.595 ml (0.00424 mol) of triethylamine were dissolved in 15 ml of toluene, treated with 0.295 ml (0.00254 mol) of benzoyl chloride and boiled at reflux for 18 hrs. The reaction mixture was concentrated and the residue was chromatographed over silica gel with ethyl acetate/hexane (1:2). 0.416 g (58%) of 1-(3-nitro-benzyl)-piperidin-4-yl benzoate was obtained as yellow crystals; m.p. 54°-55°.

Provenance & Evidence