HCID 18919855, compound → HCID 18919852, compound

Participants

Reaction Steps

0.207 g (0.0006 mol) of 1-(3-nitro-benzyl)-piperidin-4-yl benzoate was dissolved in 12 ml of ethanol and treated with 0.12 g of Raney-nickel. The mixture was hydrogenated at room temperature and under normal pressure for 8 hrs. The catalyst was filtered off and, after concentration, the residue was chromatographed on silica gel with ethyl acetate/hexane (1:1) as the eluent. 0.097 g (52%) of 1-(3-amino-benzyl)-piperidin-4-yl benzoate was obtained as yellowish crystals; m.p. 95°-97°.

Provenance & Evidence