1-(3-Nitro-benzyl)-piperidin-4-yl 4-methyl-benzoate → HCID 18919819, compound

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Reaction Steps

0.496 g (0.0014 mol) of 1-(3-nitro-benzyl)-piperidin-4-yl 4-methyl-benzoate was dissolved in 28 ml of ethanol and treated with 0.3 g of Raney-nickel. The mixture was hydrogenated at room temperature and under normal pressure for 4 hrs. The catalyst was filtered off and, after concentration, the residue was chromatographed on silica gel with ethyl acetate/ hexane (1:1→2:1) as the eluent. 0.37 g (81.5%) of 1-(3-amino-benzyl)-piperidin-4-yl 4-methyl-benzoate was obtained as yellowish crystals; m.p. 100°-102°.

Provenance & Evidence