HCID 18919752, compound → HCID 18919771, compound

Participants

Reaction Steps

0.13 g (0.00038 mol) of 1-(4-nitro-benzyl)-piperidin-4-yl benzoate was dissolved in 7.6 ml of ethanol and treated with 0.08 g of Raney-nickel. The mixture was hydrogenated at room temperature and under normal pressure for 2 hrs. The catalyst was filtered off and, after concentration, the residue was chromatographed on silica gel with ethyl acetate/hexane (1:1) as the eluent. 0.1 g (84%) of 1-(4-amino-benzyl)-piperidin-4-yl benzoate was obtained as a yellowish oil. MS: me/e=311 (C19H23N2 O2+).

Provenance & Evidence