Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl chloride → 1-(4-Methyl-benzyl)-piperidin-4-yl benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-(4-Methylbenzyl)piperidin-4-ol | HCID 791482 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-(4-Methyl-benzyl)-piperidin-4-yl benzoate | HCID 9839641 | 64% |
반응 단계
0.31 g (0.0015 mol) of 1-(4-methyl-benzyl)-piperidin-4-ol and 0.52 ml (0.00375 mol) of triethylamine were dissolved in 15 ml of toluene, treated with 0.25 ml (0.00215 mol) of benzoyl chloride and boiled at reflux for 18 hrs. The reaction mixture was concentrated and the residue was chromatographed over silica gel with ethyl acetate/hexane (1:4). 0.295 g (64%) of 1-(4-methyl-benzyl)-piperidin-4-yl benzoate was obtained as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05753679 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-6e7a7e9f27eb4ea0bbeebedc2a1f979a |
| 출처 메모 | uspto-grants-1998_05 |