HCID 18919774, compound → HCID 18919904, compound

HRID 1291179Notes

Reaction equation

HRID 1291179 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][C:16]3[CH:17]=[CH:18][C:19]([Br:22])=[CH:20][CH:21]=3)[CH2:13][CH2:14]2)=[O:7])=[CH:23][CH:24]=1

Participants

3

Reactant 1

HCID 18919774HCID 18919774, compound

Product 1

HCID 18919904HCID 18919904, compoundYield 153.6%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

0.204 g (0.00055 mol) of 1-(4-bromo-benzyl)-piperidin-4-yl 4-chloro-benzoate was dissolved in 15 ml of ether, filtered, diluted with 0.75 ml of methanol and treated with 5ml of 1N ethereal HCI. The separated precipitate was filtered off and dried. 0.188 g (83.6%) of 1-(4-bromo-benzyl)-piperidin-4-yl 4-chloro-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 240°-242°.

Workup

  1. filtrationfiltered
  2. additiondiluted with 0.75 ml of methanol
  3. additiontreated with 5ml of 1N ethereal HCI
  4. filtrationThe separated precipitate was filtered off
  5. customdried

Sources & evidence

ORD record
ord-3ec2cd5e79e64bee8bd19a69eb75d81a
Source dataset
uspto-grants-1998_05
Patent number
US05753679

Reaction notes

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