HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → (2R)-2-(2,4-difluorophenyl)-2-[(1R)-1-[1-(2,4-difluorophenyl)-2-imidazolyloxy]ethyl]oxirane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol | HCID 10631861 | — |
| Reactant | 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-(2,4-difluorophenyl)-2(1H,3H)-imidazolone | HCID 15285744 | — |
| Reactant | 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone | HCID 19065092 | — |
| Product | (2R)-2-(2,4-difluorophenyl)-2-[(1R)-1-[1-(2,4-difluorophenyl)-2-imidazolyloxy]ethyl]oxirane | HCID 53853960 | 27.4% |
Reaction Steps
In the same manner as in Reference Example 5, starting from 1.36 g of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol and 1.06 g of 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone, 0.53 g of 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-(2,4-difluorophenyl)-2(1H,3H)-imidazolone and 0.56 g of (2R)-2-(2,4-difluorophenyl)- 2-[(1R)-1-[1-(2,4-difluorophenyl)-2-imidazolyloxy]ethyl]oxirane were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05466820 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-96e999e09cdd4ac798a9b819404803ea |
| Source note | uspto-grants-1995_11 |