HCID 18919005, compound → HCID 18919292, compound

Participants

Reaction Steps

In 20% aqueous acetic acid (15 ml) was dissolved ethyl 1-[4-(4-chlorobenzoyl)benzyl]-5-(diethoxymethyl)-imidazole-4-carboxylate (1.70 g) and the solution was stirred at room temperature for 23 hours. This solution was diluted with water and extracted with ethyl acetate. The extract was washed serially with water, saturated aqueous NaHCO3 solution, and water and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to provide the title compound as white powder (1.37g; yield 95%). 1H-NMR (CDCl3) δ: 1.45(3H,t,J=7.2Hz), 4.47(2H,q,J=7.2Hz), 5.65(2H,s), 7.28(2H,d,J=8.4Hz), 7.46(2H,d,J=8.4Hz), 7.69-7.77(5H,m), 10.51(1H,s).

Provenance & Evidence